Insulin treatment of diabetic rats reduces cardiac function in a lipopolysaccharide-induced systemic inflammation model
| Autor: | Takayuki Noguchi, Satoshi Hagiwara, Kyosuke Kudo, Hideo Iwasaka, Jyunya Kusaka, Akira Hasegawa, Tomohisa Uchida |
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| Rok vydání: | 2010 |
| Předmět: |
Cardiac function curve
Blood Glucose Lipopolysaccharides Male medicine.medical_specialty Heart Diseases medicine.medical_treatment Inflammation Systemic inflammation Proinflammatory cytokine Diabetes Mellitus Experimental Sepsis Internal medicine Diabetes mellitus medicine Animals Hypoglycemic Agents Insulin Rats Wistar Nitrites Nitrates business.industry Interleukin-6 Tumor Necrosis Factor-alpha medicine.disease Rats Disease Models Animal Endocrinology Cytokine Heart Function Tests Surgery medicine.symptom business |
| Zdroj: | The Journal of surgical research. 171(1) |
| ISSN: | 1095-8673 |
| Popis: | Background Diabetes is a common comorbidity in patients with various medical conditions. Tight glucose control is known to improve systemic inflammation; however, whether it is effective in diabetic patients is unknown. The purpose of this study was to examine how strict glucose control affects systemic inflammation in diabetic patients. Materials and Methods Male Wistar rats. We determined the effect of insulin therapy on cardiac function in a rat model of systemic inflammation. We administered lipopolysaccharide intravenously, with or without insulin, to streptozotocin-induced diabetic rats. After induction of systemic inflammation, we determined serum cytokine (IL-6 and TNFα) and nitrate/nitrite levels and measured cardiac function. Results Cytokine levels and cardiac function were significantly reduced in diabetic rats compared to non-diabetic rats. Moreover, insulin treatment was associated with higher cytokine levels and decreased cardiac function. Conclusion In systemic inflammatory conditions, diabetes increases various proinflammatory mediators and inhibits cardiac function; insulin treatment exacerbates these effects. Thus, strict glucose control may not be desirable in diabetic patients with systemic inflammatory conditions. |
| Databáze: | OpenAIRE |
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