A prospectively randomized trial carried out by the German Hodgkin Study Group (GHSG) for elderly patients with advanced Hodgkin's disease comparing BEACOPP baseline and COPP-ABVD (study HD9elderly)
| Autor: | Andreas Engert, J.-U. Rüffer, Marcus Hentrich, Beate Pfistner, M. Wilhelmy, Hans Konrad Müller-Hermelink, Volker Diehl, Hans-Theodor Eich, M. Löffler, Eckhart Dühmke, Heinz Haverkamp, Veronika Ballova, P. Worst, Andreas Josting, R. Naumann |
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| Rok vydání: | 2005 |
| Předmět: |
BEACOPP
Aging medicine.medical_specialty medicine.medical_treatment Administration Oral Vinblastine Procarbazine BEACOPP Regimen law.invention Bleomycin Randomized controlled trial Prednisone law Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Infusions Intravenous Prospective cohort study Cyclophosphamide Aged Etoposide business.industry Hematology Hodgkin's lymphoma medicine.disease Hodgkin Disease Survival Analysis Surgery Dacarbazine Treatment Outcome Oncology ABVD Doxorubicin Vincristine Female business medicine.drug |
| Zdroj: | Annals of Oncology. 16:124-131 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdi023 |
| Popis: | In contrast to younger patients, the prognosis of elderly patients with advanced Hodgkin's disease (HD) has not improved substantially over the last 20 years. We thus carried out a prospectively randomized study (HD9(elderly)) to compare the BEACOPP regimen in this setting against standard COPP-ABVD. Between February 1993 and 1998, 75 patients aged 66-75 years with newly diagnosed HD in advanced stages were recruited into the HD9 trial as a separate stratum (HD9(elderly)). Patients were assigned to eight alternating cycles of COPP and ABVD or eight cycles of BEACOPP in baseline doses. Radiotherapy was given to initial bulky or residual disease. In total, 68 of 75 registered patients were assessable: 26 were treated with COPP-ABVD and 42 with BEACOPP baseline. There were no significant differences between COPP-ABVD and BEACOPP in terms of complete remission (76%), overall survival (50%) and freedom from treatment failure (FFTF) (46%) at 5 years. At a median follow-up of 80 months, a total of 37 patients died: 14/26 patients (54%) treated with COPP-ABVD and 23/42 patients (55%) with BEACOPP. Two patients (8%) treated with COPP-ABVD and nine patients (21%) treated with BEACOPP died of acute toxicity. Hodgkin-specific FFTF at 5 years was 55% after COPP-ABVD and 74% after BEACOPP (P=0.13). Thus, there are no differences in survival between these regimens in elderly patients. |
| Databáze: | OpenAIRE |
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