Oxidative-antioxidative systems and their relation with serum S100 B levels in patients with schizophrenia: effects of short term antipsychotic treatment

Autor: Selçuk Kirli, Emre Sarandol, Aysun Altin, Meral Demirci, Aslı Sarandöl, Cengiz Akkaya
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Ruh Sağlığı ve Hastalıkları Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı., Sarandöl, Aslı, Kirli, Selçuk, Akkaya, Cengiz, Altın, Aysun, Demirci, Meral, Sarandöl, Emre, ABE-1716-2020
Rok vydání: 2006
Předmět:
Male
medicine.medical_treatment
Pathogenesis
Ascorbic Acid
medicine.disease_cause
1st-Episode
Schizophrernia
Antipsychotic
chemistry.chemical_compound
Plasma
Negative syndrome
Malondialdehyde
Protein S100B
Vitamin E
Protein blood level
Schizophrenia
Acetylcysteine
Bipolar Disorder
Enzyme activity
Superoxide-dismutase
Whole blood
chemistry.chemical_classification
Psychiatry
Carotenoid
Fatty-acids
Neuroleptic agent
Glutathione peroxidase
Malonaldehyde
S100 Proteins
Middle Aged
Risperidone
Erythrocyte
Acid reactıve substances
Olanzapine
Clinical neurology
Female
Cell damage
Amisulpride
Psychology
Human
Vitamin blood level
Antipsychotic Agents
Adult
Psychosis
medicine.medical_specialty
Clinical article
Diagnostic and statistical manual of mental disorders
S100 Calcium Binding Protein beta Subunit
Stress
Pathophysiology
Article
Brain damage
Antioxidant activity
Internal medicine
Lipid peroxides
Oxidation
medicine
Humans
Nerve Growth Factors
Biological Psychiatry
Pharmacology
Pharmacology & pharmacy
Quetiapine
Superoxide Dismutase
Neurosciences
Proteins
Alpha tocopherol
Vitamin-c
S100 B
medicine.disease
Carotenoids
Surgery
Positive syndrome
Oxidative Stress
Endocrinology
chemistry
Degenerative disease
Case-Control Studies
Zalondialdehyde
Haloperidol
Atypical antipsychotic agent
Controlled study
Oxidative stress
Zdroj: Progress in neuro-psychopharmacologybiological psychiatry. 31(6)
ISSN: 0278-5846
Popis: Oxidative stress may be a contributing factor in the etiopathophysiology of schizophrenia, which may be exacerbated by the treatment with antipsychotics with pro-oxidant properties. Increased levels of S100 B are associated with neurodegenerative disorders, including schizophrenia. The aim of the present study was to investigate the role of oxidative cell damage in the pathogenesis of schizophrenia. Forty patients who fully met the fourth Diagnostic and Statistical Manual of Mental Disorders criteria for schizophrenia and 35 healthy control subjects were included in the study. Serum S100 B level was determined to investigate brain damage. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cell (RBC) to oxidation were determined to investigate the oxidative status and plasma vitamin E, vitamin C, serum total carotenoid levels and total antioxidant capacity and RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase activities were measured to investigate the antioxidative defence before and after 6 weeks of antipsychotic treatment. Plasma MDA and serum S100 B levels and RBC-SOD activity were significantly higher in the schizophrenia group than those of the control group. Treatment did not modify any of the oxidative-antioxidative system parameters or serum S100 B levels. S100 B level was significantly higher in patients with negative symptoms than the patients with positive symptoms and the control subjects. S100 B levels were significantly reduced after 6 weeks of treatment in patients with negative symptoms. The results of the present study might support the oxidative cell injury hypothesis of the schizophrenia. Furthermore, the underlying mechanisms of the subgroups of schizophrenia might be different as suggested by the increased S100 B levels and its decrement after treatment in patients with negative symptoms.
Databáze: OpenAIRE
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