Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
| Autor: | Olle Lindvall, Vladimer Darsalia, Emma Evergren, Konstantinos Meletis, Tasuku Honjo, Christian Göritz, Jonas Frisén, Zaal Kokaia, Luigi Naldini, Fanie Barnabé-Heider, Marie Carlén, Kenji Tanigaki, Oleg Shupliakov, Robert Cassidy, Maggie S. Y. Yeung, Mario Amendola |
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| Přispěvatelé: | Carlen, M, Meletis, K, Goritz, C, Darsalia, V, Evergren, E, Tanigaki, K, Amendola, M, Barnabe Heider, F, Yeung, Msy, Naldini, Luigi, Honjo, T, Kokaia, Z, Shupliakov, O, Cassidy, Rm, Lindvall, O, Frisen, J., Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Généthon |
| Rok vydání: | 2009 |
| Předmět: |
Ependymal Cell
[SDV.BIO]Life Sciences [q-bio]/Biotechnology Cellular differentiation Notch signaling pathway Mice Transgenic [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Mice Prosencephalon Neuroblast Ependyma medicine Animals Humans Receptor Notch1 ComputingMilieux_MISCELLANEOUS Neurons Mice Inbred ICR Stem Cells General Neuroscience Neurogenesis Cell Differentiation [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology Olfactory Bulb Growth Inhibitors Neural stem cell Stroke Phenotype medicine.anatomical_structure Astrocytes Neuron Stem cell Neuroscience |
| Zdroj: | Nature Neuroscience Nature Neuroscience, 2009, 12 (3), pp.259-267. ⟨10.1038/nn.2268⟩ |
| ISSN: | 1097-6256 1546-1726 |
| DOI: | 10.1038/nn.2268⟩ |
| Popis: | Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling. Inhibition of this pathway in uninjured animals allowed ependymal cells to enter the cell cycle and produce olfactory bulb neurons, whereas forced Notch signaling was sufficient to block the ependymal cell response to stroke. Ependymal cells were depleted by stroke and failed to self-renew sufficiently to maintain their own population. Thus, although ependymal cells act as primary cells in the neural lineage to produce neurons and glial cells after stroke, they do not fulfill defining criteria for stem cells under these conditions and instead serve as a reservoir that is recruited by injury. |
| Databáze: | OpenAIRE |
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