Low Cost Electrode Assembly for EEG Recordings in Mice
| Autor: | Daniel Flynn, Jorge Busciglio, Federico Busciglio, Emily C. Vogler, Alison Tran, Matthew Mahavongtrakul, Ryan C. Bohannan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science Brain tissue Electroencephalography Signal lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Small animal medicine Methods EEG lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Insert (composites) medicine.diagnostic_test electrode implantation General Neuroscience Neurosciences equipment and supplies neurologger 030104 developmental biology Electrode wireless electroencephalography Cognitive Science Implant 030217 neurology & neurosurgery electroencephalography Biomedical engineering Neuroscience |
| Zdroj: | Vogler, Emily C; Flynn, Daniel T; Busciglio, Federico; Bohannan, Ryan C; Tran, Alison; Mahavongtrakul, Matthew; et al.(2017). Low Cost Electrode Assembly for EEG Recordings in Mice.. Frontiers in neuroscience, 11, 629. doi: 10.3389/fnins.2017.00629. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7zp5z1b4 Frontiers in Neuroscience, Vol 11 (2017) Frontiers in Neuroscience |
| DOI: | 10.3389/fnins.2017.00629. |
| Popis: | Wireless electroencephalography (EEG) of small animal subjects typically utilizes miniaturized EEG devices which require a robust recording and electrode assembly that remains in place while also being well-tolerated by the animal so as not to impair the ability of the animal to perform normal living activities or experimental tasks. We developed simple and fast electrode assembly and method of electrode implantation using electrode wires and wire-wrap technology that provides both higher survival and success rates in obtaining recordings from the electrodes than methods using screws as electrodes. The new wire method results in a 51% improvement in the number of electrodes that successfully record EEG signal. Also, the electrode assembly remains affixed and provides EEG signal for at least a month after implantation. Screws often serve as recording electrodes, which require either drilling holes into the skull to insert screws or affixing screws to the surface of the skull with adhesive. Drilling holes large enough to insert screws can be invasive and damaging to brain tissue, using adhesives may interfere with conductance and result in a poor signal, and soldering screws to wire leads results in fragile connections. The methods presented in this article provide a robust implant that is minimally invasive and has a significantly higher success rate of electrode implantation. In addition, the implant remains affixed and produces good recordings for over a month, while using economical, easily obtained materials and skills readily available in most animal research laboratories. |
| Databáze: | OpenAIRE |
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