Discovery and Structural and Functional Characterization of a Novel A-Superfamily Conotoxin Targeting α9α10 Nicotinic Acetylcholine Receptor

Autor: Qiuyuan Huang, Xin Chu, Haoran Zhang, Shuo Yu, Longxiao Zhang, Xuerong Zhang, Rilei Yu, Chenyun Guo, Qiuyun Dai
Rok vydání: 2022
Předmět:
Zdroj: ACS chemical biology. 17(9)
ISSN: 1554-8937
Popis: Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels widely distributed in the central peripheral nervous system and muscles which participate in rapid synaptic transmission. The α9α10 nAChR is an acetylcholine receptor subtype and is involved in chronic pain. In the present study, a new A-superfamily conotoxin Bt14.12 cloned from
Databáze: OpenAIRE