Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin
| Autor: | Marty O. Visscher, Jason M. Winget, Vivek Narendran, Charles C. Bascom, Andrew N. Carr, Robert J. Isfort, Karen Lammers, Thomas G. Huggins |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
S100A7 Adult Male Proteomics Aging Protein biomarkers medicine.medical_treatment Skin Absorption Physiology Biophysical Phenomena Desquamation 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Late preterm Medicine Humans Clinical Research Article Protease integumentary system business.industry Infant Newborn Proteins Correction Antimicrobial 030104 developmental biology Pediatrics Perinatology and Child Health Female medicine.symptom business Neonatal skin Biomarkers Infant Premature Filaggrin |
| Zdroj: | Pediatric Research |
| ISSN: | 1530-0447 |
| Popis: | BackgroundThe objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).MethodsSkin samples of 61 neonates and 34 adults were analyzed for protein biomarkers, natural moisturizing factor (NMF), and biophysical parameters. Infant groups were: ResultsForty proteins were differentially expressed in FT infant skin, 38 in LPT infant skin, and 12 in PT infant skin compared with adult skin at T1. At T2, 40 proteins were differentially expressed in FT infants, 38 in LPT infants, and 54 in PT infants compared with adults. All proteins were increased at both times, except TMG3, S100A7, and PEBP1, and decreased in PTs at T1. The proteins are involved in filaggrin processing, protease inhibition/enzyme regulation, and antimicrobial function. Eight proteins were decreased in PT skin compared with FT skin at T1. LPT and FT proteins were generally comparable at both times. Total NMF was lower in infants than adults at T1, but higher in infants at T2.ConclusionsNeonates respond to the physiological transitions at birth by upregulating processes that drive the production of lower pH of the skin and water-binding NMF components, prevent protease activity leading to desquamation, and increase the barrier antimicrobial properties.ImpactNeonates respond to the transitions at birth by upregulating processes that drive the production of lower pH of the skin and NMF, prevent protease activity leading to desquamation, and increase the antimicrobial properties of the barrier.The neonatal epidermal barrier exhibits a markedly different array of protein biomarkers both shortly after birth and 2–3 months later, which are differentially expressed versus adults.The major biomarker-functional classes included filaggrin processing, protease inhibitor/enzyme regulators, antimicrobials, keratins, lipids, and cathepsins.The findings will guide improvement of infant skin care practices, particularly for the most premature infants with the ultimate goals mitigating nosocomial infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink