Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population
| Autor: | Jian Wang, Jia Fan, Wenjun Zhou, Bo Chen, Feng Xu, Yuefeng Sheng, Peng Yang, Hongwei Ye, Yaoliang Shen, Chunyang Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
China
Prospective Clinical Research Report Medicine (General) Genotype Angiotensin-converting enzyme gene Biochemistry polymorphism R5-920 Gene Frequency parasitic diseases Medicine Cytochrome P-450 CYP11B2 Humans cardiovascular diseases Allele restriction fragment length polymorphism Genetics Chinese population Polymorphism Genetic business.industry Biochemistry (medical) allele Cell Biology General Medicine nervous system diseases CYP11B2 Ischemic Attack Transient transient ischemic attack Hypertension Restriction fragment length polymorphism business |
| Zdroj: | Journal of International Medical Research, Vol 48 (2020) The Journal of International Medical Research |
| ISSN: | 1473-2300 |
| Popis: | Objective This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility. Methods We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR–RFLP). Results The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons. Conclusion Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population. |
| Databáze: | OpenAIRE |
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