Chromosome Positioning in Spermatozoa
| Autor: | Olga Mudrak, Irina Zalenskaya, Andrei O. Zalensky |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Sperm Chromatin for the Researcher ISBN: 9781461484585 Sperm Chromatin ISBN: 9781441917812 |
| DOI: | 10.1007/978-1-4614-8459-2_4 |
| Popis: | Similar to interphase chromosomes, mammalian supercompact and genetically inactive sperm chromatin is arranged in non-overlapping chromosome territories. Recent works demonstrate that chromosome territories in sperm have defined and nonrandom intranuclear positioning. It is hypothesized that preferred localization of chromosomes in sperm together with well-organized chromosome architecture provide epigenetic signature to genome, which might be important at fertilization and early development. Here, we describe relevant experimental data with primary attention to the studies related to human spermatozoa. Possible implications of sperm chromosome positioning for modern reproductive technologies are discussed. |
| Databáze: | OpenAIRE |
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