Dengue tropism for macrophages and dendritic cells: the host cell effect
| Autor: | Mayra Diosa-Toro, Jacky Flipse, Silvio Urcuqui-Inchima, Izabela A. Rodenhuis-Zybert, Jolanda M. Smit, Silvia Torres Pedraza, José Herrera-Rodriguez, Heidi van der Ende-Metselaar, Anke Huckriede |
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| Přispěvatelé: | Microbes in Health and Disease (MHD), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
TISSUES viruses 030106 microbiology CLEC5A VIRUS-INFECTION Dengue virus Biology Virus Replication medicine.disease_cause Virus DISEASE Microbiology Dengue fever Dengue 03 medical and health sciences Immune system Virology medicine Humans PARTICLES Antibody-dependent enhancement Cells Cultured Tropism ANTIBODY-DEPENDENT ENHANCEMENT Infectivity Macrophages Dendritic Cells Dengue Virus medicine.disease 030104 developmental biology ENTRY Tissue tropism TARGET-CELLS |
| Zdroj: | The Journal of general virology, 97, 1531-1536. AMER SOC MICROBIOLOGY |
| ISSN: | 0022-1317 |
| Popis: | Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC derived virus. Taken together, our results highlight the importance of macrophages in dengue infection. |
| Databáze: | OpenAIRE |
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