How does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis
| Autor: | Maria Rasmussen Rinnov, Nina Haarup Ravn, Anne-Sofie Halling, Aviva G. Berkowitz, Jacob P. Thyssen, Jonathan I. Silverberg, Alexander Egeberg |
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| Rok vydání: | 2019 |
| Předmět: |
Hypersensitivity
Immediate Parents Risk medicine.medical_specialty Immunology Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Internal medicine Immunology and Allergy Medicine Humans 030212 general & internal medicine Risk factor Child Medical History Taking Asthma business.industry Odds ratio Atopic dermatitis medicine.disease Newcastle–Ottawa scale Systematic review 030228 respiratory system Meta-analysis Relative risk Disease Susceptibility business |
| Zdroj: | The Journal of allergy and clinical immunology. 145(4) |
| ISSN: | 1097-6825 |
| Popis: | Background Parental history of atopic disease is a well-established risk factor for the development of atopic dermatitis (AD), but several aspects of this association remain unclear. Objective We sought to determine the association of parental history of atopic disease with AD in offspring. Methods We searched PubMed and EMBASE through June 2018 for relevant records and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pooled odds ratios (ORs) with 95% CI were calculated using random-effects models. Results A total of 163 records covering 149 unique studies were included. Of these, 119 studies were included in the meta-analysis. Individuals with parental history of atopic disease had increased odds of AD (OR, 1.81; 95% CI, 1.65-1.99). Parental asthma (OR, 1.56; 95% CI, 1.18-2.05) and allergic rhinitis (OR, 1.68; 95% CI, 1.34-2.11) had a smaller effect than AD (OR, 3.30; 95% CI, 2.46-4.42). The effect of maternal and paternal history was comparable for all atopic diseases. An increase in odds was observed when comparing the effect of having 1 (OR, 1.30; 95% CI, 1.15-1.47) or 2 atopic parents (OR, 2.08; 95% CI, 1.83-2.36), as well as having a parent with 1 (OR, 1.49; 95% CI, 1.28-1.74) or more atopic diseases (OR, 2.32; 95% CI, 1.92-2.81). Conclusions This study provides evidence-based risk estimates that may guide physicians who counsel parents with a history of atopic disease about their children's risk of AD. This information is of particular importance for future efforts toward establishing prophylactic interventions for AD on a general population level. |
| Databáze: | OpenAIRE |
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