Application of guidelines for aminoglycosides use in French hospitals in 2013–2014

Autor: Jérôme Robert, Jean-Pierre Bedos, Christian Rabaud, Serge Alfandari, Yves Pean, J.P. Bru, R. Gauzit
Přispěvatelé: Centre d'Immunologie et de Maladies Infectieuses (CIMI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Bactériologie et d'Hygiène Hospitalière [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Observatoire National de l’Épidémiologie de la Résistance Bactérienne aux Antibiotiques (ONERBA), Dpt Réanimation-Maladies infectieuses [CH G. Dron], Centre Hospitalier Gustave Dron, Dpt infectiologie [CH Annecy], Centre hospitalier de la région d'Annecy, Dpt Soins intensifs [CH Henri Mignot de Versailles], Centre Hospitalier de Versailles André Mignot (CHV), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), HAL UPMC, Gestionnaire, Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2017, 36 (7), pp.1083-1090. ⟨10.1007/s10096-016-2892-5⟩
European Journal of Clinical Microbiology and Infectious Diseases, 2017, 36 (7), pp.1083-1090. ⟨10.1007/s10096-016-2892-5⟩
ISSN: 0934-9723
1435-4373
Popis: on behalf of the Société de Pathologie Infectieuse de Langue Française (SPILF), the Observatoire National de l’Epidémiologie de la Résistance Bactérienne aux Antibiotiques (ONERBA) and the Surveillance de la Prescription des Antibiotiques (SPA) group; International audience; In 2011, the French Agency for Safety of Health Products issued guidelines underlining the principles of proper aminoglycosides’ use. The aim of the survey was to evaluate adherence to these guidelines two years after their issue. Characteristics of patients receiving aminoglycosides were recorded by voluntary facilities during a 3-month survey in 2013–2014. The modalities of aminoglycosides treatment were analysed by comparison with the French guidelines. A total of 3,323 patients were included by 176 facilities. Patients were mainly hospitalized in medical wards (33.0%), and treated for urinary-tract infections (24.7%). Compliance regarding the clinical indication and the daily aminoglycosides dose was observed in 65.2% and 62.9% of the cases, respectively. A 30-min once-daily IV administration was recorded in 62.5% of the cases. Aminoglycosides treatment duration was appropriate (≤5 days) for 93.6% of the patients. When considering the four criteria together, 23.2% of the patients had a treatment regimen aligned with the guidelines. Requests for measurements of peak and trough AG serum concentrations matched the guidelines in 24.9% and 67.4% of the cases, respectively. Two years after guidelines issue, aminoglycosides use remains unsatisfactory in French health-care facilities. Efforts should be made for guidelines promotion, especially regarding the issue of underdosing.
Databáze: OpenAIRE
Externí odkaz: