Hypereosinophilic Syndrome After Liver Transplantation: A Case Report and a Review of the Literature
| Autor: | Enke Grabhorn, Anne Katrin Dettmar, Wiebke Aulbert, Christian Breuer, Markus J. Kemper, Robin Kobbe, Florian Brinkert, Hansjörg Schäfer, Andrea Briem-Richter |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain medicine.medical_treatment Hypereosinophilia Liver transplantation Gastroenterology 03 medical and health sciences 0302 clinical medicine Postoperative Complications Biliary atresia Internal medicine Hypereosinophilic Syndrome medicine Eosinophilia Humans Child Transplantation Hypereosinophilic syndrome business.industry medicine.disease Liver Transplantation 030220 oncology & carcinogenesis Prednisolone medicine.symptom Differential diagnosis business 030215 immunology medicine.drug |
| Zdroj: | Transplantation. 101(5) |
| ISSN: | 1534-6080 |
| Popis: | Persistently elevated eosinophil granulocytes in the peripheral blood in children is challenging because of a complex diagnosis especially after solid organ transplantation and can lead to difficulties in finding an underlying causative factor.We report a 12-year-old boy who developed severe hypereosinophilia 11 years after liver transplantation due to biliary atresia. Accompanying symptoms were recurrent fever, fatigue, elevated liver enzymes, abdominal pain, and significant weight loss. After exclusion of secondary causes of eosinophilia, an idiopathic hypereosinophilic syndrome (I-HES) was diagnosed. Treatment with prednisolone resulted in an immediate response with rapid reduction of eosinophils, normalization of liver enzymes, and amelioration of any clinical symptoms. A hypereosinophilic syndrome in patients after liver transplantation is rare, and a broad differential diagnosis has to be considered. Prednisolone may lead to a prompt amelioration of eosinophilia and associated symptoms. |
| Databáze: | OpenAIRE |
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