Treatment Response Score to Glatiramer Acetate or Interferon Beta-1a
| Autor: | Francois Grand'Maison, Eva Havrdova, Serkan Ozakbas, Ayse Altintas, Gary Cutter, Cavit Boz, Cristina Ramo-Tello, Pierre Grammond, Marco Onofrj, Patrizia Sola, Francesca Bovis, Pierre Duquette, Diana Ferraro, Recai Turkoglu, Elisabetta Cartechini, Pamela A. McCombe, Roberto Bergamaschi, Aysun Soysal, Sara Eichau, Celia Oreja-Guevara, Alexandre Prat, Murat Terzi, Raymond Hupperts, Vincent Van Pesch, Guillermo Izquierdo, Dana Horakova, Charles B Malpas, Jerry S. Wolinsky, Helmut Butzkueven, Tomas Kalincik, Marc Girard, Claudio Solaro, Gerardo Iuliano, Alessandra Lugaresi, Francesco Patti, Fred D. Lublin, Maria Pia Sormani, Maria Trojano, Thor Petersen |
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| Přispěvatelé: | DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Databases Factual Relapsing-Remitting Injections Intramuscular Article law.invention Injections Cohort Studies 03 medical and health sciences Databases 0302 clinical medicine Multiple Sclerosis Relapsing-Remitting Randomized controlled trial Adjuvants Immunologic law Immunologic Internal medicine medicine Humans 030212 general & internal medicine Female Glatiramer Acetate Immunosuppressive Agents Interferon beta-1a Middle Aged Treatment Outcome Adjuvants Glatiramer acetate Factual Intramuscular Expanded Disability Status Scale business.industry Confidence interval Quartile Cohort Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug Cohort study |
| Zdroj: | Neurology r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Neurology, (2020) |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | none 39 si OBJECTIVE: To compare the effectiveness of glatiramer acetate (GA) vs intramuscular interferon beta-1a (IFN-β-1a), we applied a previously published statistical method aimed at identifying patients' profiles associated with efficacy of treatments. METHODS: Data from 2 independent multiple sclerosis datasets, a randomized study (the Combination Therapy in Patients With Relapsing-Remitting Multiple Sclerosis [CombiRx] trial, evaluating GA vs IFN-β-1a) and an observational cohort extracted from MSBase, were used to build and validate a treatment response score, regressing annualized relapse rates (ARRs) on a set of baseline predictors. RESULTS: The overall ARR ratio of GA to IFN-β-1a in the CombiRx trial was 0.72. The response score (made up of a linear combination of age, sex, relapses in the previous year, disease duration, and Expanded Disability Status Scale score) detected differential response of GA vs IFN-β-1a: in the trial, patients with the largest benefit from GA vs IFN-β-1a (lower score quartile) had an ARR ratio of 0.40 (95% confidence interval [CI] 0.25-0.63), those in the 2 middle quartiles of 0.90 (95% CI 0.61-1.34), and those in the upper quartile of 1.14 (95% CI 0.59-2.18) (heterogeneity p = 0.012); this result was validated on MSBase, with the corresponding ARR ratios of 0.58 (95% CI 0.46-0.72), 0.92 (95% CI 0.77-1.09,) and 1.29 (95% CI 0.97-1.71); heterogeneity p < 0.0001). CONCLUSIONS: We demonstrate the possibility of a criterion, based on patients' characteristics, to choose whether to treat with GA or IFN-β-1a. This result, replicated on an independent real-life cohort, may have implications for clinical decisions in everyday clinical practice. open Bovis F.; Kalincik T.; Lublin F.; Cutter G.; Malpas C.; Horakova D.; Havrdova E.K.; Trojano M.; Prat A.; Girard M.; Duquette P.; Onofrj M.; Lugaresi A.; Izquierdo G.; Eichau S.; Patti F.; Terzi M.; Grammond P.; Bergamaschi R.; Sola P.; Ferraro D.; Ozakbas S.; Iuliano G.; Boz C.; Hupperts R.; Grand'Maison F.; Oreja-Guevara C.; van Pesch V.; Cartechini E.; Petersen T.; Altintas A.; Soysal A.; Ramo-Tello C.; McCombe P.; Turkoglu R.; Butzkueven H.; Wolinsky J.S.; Solaro C.; Sormani M.P. Bovis F.; Kalincik T.; Lublin F.; Cutter G.; Malpas C.; Horakova D.; Havrdova E.K.; Trojano M.; Prat A.; Girard M.; Duquette P.; Onofrj M.; Lugaresi A.; Izquierdo G.; Eichau S.; Patti F.; Terzi M.; Grammond P.; Bergamaschi R.; Sola P.; Ferraro D.; Ozakbas S.; Iuliano G.; Boz C.; Hupperts R.; Grand'Maison F.; Oreja-Guevara C.; van Pesch V.; Cartechini E.; Petersen T.; Altintas A.; Soysal A.; Ramo-Tello C.; McCombe P.; Turkoglu R.; Butzkueven H.; Wolinsky J.S.; Solaro C.; Sormani M.P. |
| Databáze: | OpenAIRE |
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