Microcystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature
| Autor: | Ethan James Harris, Tom Thomas, Allen C. Lam, Nicole G. Chau, Roy B. Tishler, Grace M. Lee, Daniel Wonsoon Kim, Miranda B. Lam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty lcsh:R895-920 Locally advanced Asymptomatic lcsh:RC254-282 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Radiology Nuclear Medicine and imaging Nose Microcystic adnexal carcinoma Philtrum Skin Neoplasm business.industry Teaching Case medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Nonsurgical treatment Carboplatin medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis Radiology medicine.symptom business |
| Zdroj: | Advances in Radiation Oncology, Vol 5, Iss 2, Pp 301-310 (2020) Advances in Radiation Oncology |
| ISSN: | 2452-1094 |
| Popis: | Background Microcystic adnexal carcinoma (MAC) is a rare, locally invasive skin neoplasm most commonly in the head and neck. MAC is routinely treated surgically and scant data is available regarding the role of definitive chemoradiotherapy (chemoRT) as a surgical alternative. Methods A single case of MAC treated with upfront chemoRT is presented along with a review of the literature. Results A 73-year old man with locally advanced MAC of the philtrum and nose declined surgery and was treated with concurrent intensity-modulated RT (70Gy) and paclitaxel/carboplatin. His tumor responded clinically within two weeks of treatment. Partial radiographic response was observed at three months with improvement up to one year post-treatment. He remains asymptomatic and progression-free six years from the completion of his treatment. Conclusion Definitive chemoRT may be a nonsurgical treatment alternative for MAC when surgery is not possible or declined. |
| Databáze: | OpenAIRE |
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