Inhibitory Effect of Dehydroevodiamine and Evodiamine on Nitric Oxide Production in Cultured Murine Macrophages
| Autor: | Chieh-Fu Chen, Yen-Jen Sung, § and Andrew Yau-Chik Shum, Wen-Fei Chiou, Jyh-Fei Liao |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Lipopolysaccharides
Pharmaceutical Science Pharmacology Nitric Oxide Analytical Chemistry Nitric oxide Interferon-gamma Mice chemistry.chemical_compound Alkaloids Evodiamine Drug Discovery medicine Animals Interferon gamma Cells Cultured Plant Extracts Chemistry Macrophages Alkaloid Organic Chemistry Biological activity In vitro Complementary and alternative medicine Mechanism of action Biochemistry Cell culture Quinazolines Molecular Medicine medicine.symptom medicine.drug |
| Zdroj: | Journal of Natural Products. 60:708-711 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np960495z |
| Popis: | Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their effects on NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 and 2 inhibited the IFN-gamma/LPS-stimulated NO production in a concentration-dependent manner. However, 1 appeared to inhibit NO production by interfering not only with the priming signal initiated by IFN-gamma but also with iNOS protein synthesis, while 2 affected the former only. |
| Databáze: | OpenAIRE |
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