CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES

Autor:	Dick Pluim, Mark T. J. van Bussel, Bojana Milojkovic-Kerklaan, Jan H.M. Schellens, Emilie Le Rhun, Daan van den Broek, Dieta Brandsma, Jos H. Beijnen, Willem Boogerd
Rok vydání:	2017
Předmět:	Cancer Research Pathology medicine.medical_specialty Contrast enhancement business.industry Leptomeninges Melanoma Tumor cells medicine.disease Abstracts Cerebrospinal fluid Oncology Mutation testing Medicine Sampling (medicine) Neurology (clinical) business Cytometry
Zdroj:	Neuro-Oncology. 19:vi41-vi41
ISSN:	1523-5866 1522-8517
Popis:	INTRODUCTION Approximately five percent of melanoma patients develop leptomeningeal metastases (LM). Diagnosis of LM can be made on clinical symptoms and typical contrast enhancement of the leptomeninges on MRI brain or spine and/or CSF cytology. However, MRI has a sensitivity of 76% and a specificity of 77%. Sensitivity of CSF cytology is also low: 55% at first analysis, increasing to 80% upon second sampling.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8f444071174f160ac94107a96fe31f https://doi.org/10.1093/neuonc/nox168.161 Zobrazit plný text záznamu