Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion
| Autor: | Oscar K. Reiss, Lance S. Terada, J. R. Schwappach, P. F. Shanley, Jonathan A. Leff, H. J. McCutchan, John E. Repine, E. G. Enquist, D. L. Walden |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils Physiology Neutrophile medicine.medical_treatment Ischemia Sodium Chloride Vinblastine Leukocyte Count Gastrocnemius muscle Physiology (medical) Internal medicine Edema medicine Animals Saline business.industry Muscles Skeletal muscle Blood neutrophils Rats Inbred Strains medicine.disease Rats medicine.anatomical_structure Endocrinology Reperfusion Immunology medicine.symptom Cardiology and Cardiovascular Medicine business Muscle Contraction medicine.drug |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 259:H1809-H1812 |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion. |
| Databáze: | OpenAIRE |
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