Effect of aqueous extracts of Ficus vogeliana Miq and Tieghemella africana Pierre in 7,12-Dimethylbenz(a)anthracene -induced skin cancer in rats
| Autor: | Jean De La Croix Ndong, Hugue Ella Mendene, Barthelemy Mabika, Felix Ovono Abessolo, Nan Gao, Cédric Sima Obiang, Miguel Cervantes-Cervantes, Aurelia Vergeade, Jean Engohang-Ndong, Guillaume Vignaux, Louis Clément Obame Engonga, Fleury Augustin Nsole Biteghe, Rick Léonid Ngoua Meye Misso, Joseph Privat Ondo |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Skin Neoplasms Antioxidant DPPH 9 10-Dimethyl-1 2-benzanthracene medicine.medical_treatment Ficus Chick Embryo Terpene 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery medicine Animals Rats Wistar IC50 030304 developmental biology Pharmacology Sapotaceae 0303 health sciences biology Traditional medicine Plant Extracts 7 12-Dimethylbenz[a]anthracene Water biology.organism_classification Rats Treatment Outcome chemistry Phytochemical Polyphenol 030220 oncology & carcinogenesis Carcinogens |
| Zdroj: | Journal of Ethnopharmacology. 263:113244 |
| ISSN: | 0378-8741 |
| Popis: | Ethnopharmacological relevance Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality. Tieghemella africana and Ficus vogeliana are used in traditional medicine to treat cancers. Aim of the study Therefore, the aim of this study was to investigate the antioxidant, antiangiogenic and anti-tumor activities of these plant extracts. Materials and methods To achieve it, phytochemical screening, antioxidant activity and antiangiogenic activity were assessed. Thereafter, the anti-tumor activity was determined using skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene. Results The phytochemical result analysis showed that both plant extracts were rich in polyphenols, alkaloids and terpene compounds and possessed good antioxidant activity based on DPPH radical scavenging (IC50 = 9.70 μg/mL and 4.60 μg/mL and AAI values of 5.20 and 10.88) and strong total antioxidant capacity (115.44 VtCE (mg)/g of dry plant extract and 87.37 VtCE (mg)/g of dry plant extract, respectively). Additionally, both plant extracts possessed antiangiogenic activities (IC50= 53.43 μg/mL and 92.68 μg/mL, respectively), which correlated with significant antitumor activities when using 35 mg/kg (65.02% and 77.54 %) and 70 mg/kg of extracts (81.07% and 88.18%). Conclusions In summary, this study illustrates the promising usage of Tieghemella africana and Ficus vogeliana plant extracts in treating skin cancer. However, further characterization of the extracts must be performed to isolate the most active anticancer compound. |
| Databáze: | OpenAIRE |
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