The BCL-2 Family Reunion
| Autor: | Douglas R. Green, Melissa J. Parsons, Jerry E. Chipuk, Fabien Llambi, Tudor Moldoveanu |
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| Rok vydání: | 2010 |
| Předmět: |
Molecular Sequence Data
Apoptosis Context (language use) Biology Endoplasmic Reticulum Models Biological Permeability Article Outer mitochondrial membrane Autophagy Amino Acid Sequence Molecular Biology Genetics Bcl-2 family Cell Biology Cell biology Proto-Oncogene Proteins c-bcl-2 Multigene Family Mitochondrial Membranes Signal transduction Sequence Alignment B-cell CLL Function (biology) Signal Transduction |
| Zdroj: | Molecular Cell. 37:299-310 |
| ISSN: | 1097-2765 |
| Popis: | B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions. |
| Databáze: | OpenAIRE |
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