MTHFR rs1801133 polymorphism is associated with increased risk of B-cell precursor lymphoblastic leukaemia with recurrent genetic aberrations of fetal origin
| Autor: | Alython Araujo Chung-Filho, Gisele Dallapicola Brisson, Paulo Chagas-Neto, Sheila C. Soares‐Lima, Maria S. Pombo-de-Oliveira, Tállita Mecianny Farias Vieira |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Genotype Epidemiology Disease Logistic regression 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Genetic predisposition Humans Genetic Predisposition to Disease 030212 general & internal medicine Child Genotyping Methylenetetrahydrofolate Reductase (NADPH2) Fetus Polymorphism Genetic biology business.industry Infant Newborn Infant Odds ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma KMT2A 030220 oncology & carcinogenesis Methylenetetrahydrofolate reductase Case-Control Studies Child Preschool biology.protein Female business |
| Zdroj: | Cancer epidemiology. 65 |
| ISSN: | 1877-783X |
| Popis: | Background Childhood acute lymphoblastic leukaemia (ALL) is a heterogeneous disease associated with multiple risk factors including genetic susceptibility. Polymorphisms in folate genes have been associated with a protective effect against ALL, although some studies contradict these findings. We aimed to test whether there is an association between the MTHFR rs1801133 variant and the occurrence of B-cell precursor ALL (BCP-ALL) taking in account molecularly distinct subtypes of fetal origin. Methods We performed a case-control genotyping study with 2067 samples, 1309 ALL and 758 controls, from children aged ≤ 15 years for MTHFR rs1801133 polymorphism. Risk associations were calculated by odds ratios estimated with unconditional logistic regression, adjusted for frequency-matched ethnic groups. Results Overall, MTHFR rs1801133 does not impact ALL risk in children with more than 6 years of age. A significant positive association for MTHFR rs1801133 variant was found for ALL with KMT2A-r in the dominant model (adj. OR, 1.48, 95 % CI, 1.01–2.17), while ETV6-RUNX1 and Hyperdiploid subgroups have shown a borderline effect (adj. OR, 1.33, 95 % CI, 0.99–1.78). Conclusions The polymorphism MTHFR rs1801133 increased the risk of infant ALL in Brazilian population. |
| Databáze: | OpenAIRE |
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