Angiolymphoid hyperplasia with eosinophilia: evidence for a T-cell lymphoproliferative origin
| Autor: | Renato G. Panizzon, Andreas C. Haeffner, Beatrix Mueller, Karoline Zepter, Günter Burg, Christian Sander, Volker Adams, Werner Kempf, Thomas Hardmeier, Michael J. Flaig |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Population Biology Histogenesis Polymerase Chain Reaction Pathology and Forensic Medicine Pathogenesis T-Lymphocyte Subsets medicine Eosinophilia Humans Angiolymphoid hyperplasia with eosinophilia education Aged education.field_of_study Gene Rearrangement gamma-Chain T-Cell Antigen Receptor Cutaneous T-cell lymphoma Angiolymphoid Hyperplasia with Eosinophilia Cell Differentiation Receptors Antigen T-Cell gamma-delta Gene rearrangement Middle Aged medicine.disease Lymphoma Immunology Herpesvirus 8 Human Female medicine.symptom Cell Division |
| Zdroj: | Human pathology. 33(10) |
| ISSN: | 0046-8177 |
| Popis: | Angiolymphoid hyperplasia with eosinophilia (ALHE) is commonly regarded an angioproliferative process characterized by the presence of prominent, bizarrely shaped blood vessels. These vessels are accompanied by an inflammatory infiltrate that is thought to be a reactive component. Both the cell of origin and the pathogenesis of ALHE remain controversial. To define the histogenesis of this disorder, we analyzed the phenotypic and genotypic profile of the inflammatory infiltrate in ALHE by immunohistochemistry and T-cell receptor gene rearrangement by polymerase chain reaction (PCR) and denaturing gradient gel electrophoresis, as well as automated high-resolution PCR fragment analysis. Five of 7 ALHE patients displayed a clonal T-cell population and proliferative T-cell activity in lesional tissue. Most of these cases followed a protracted and therapy-reluctant course with recurrences. These data suggest that ALHE or a subset of ALHE cases harboring a clonal T-cell population may represent a T-cell lymphoproliferative disorder of a benign or low-grade malignant nature. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect