Iron-induced platelet aggregation measurement
| Autor: | J. P. Ottervanger, Robbert J. Slingerland, J. J. J. Smit, Felix Zijlstra, W. van Oeveren, J. A. Remijn, A. W. J. van 't Hof |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Platelet Aggregation medicine.medical_treatment platelet function Clinical Biochemistry Myocardial Infarction Pilot Projects Biochemistry ST segment Platelet Myocardial infarction SUBACUTE THROMBOSIS ASPIRIN RESISTANCE General Medicine Tirofiban Middle Aged Clopidogrel STAINLESS-STEEL STENTS PREDICTS Treatment Outcome platelets Cardiology Female Stents medicine.drug Agonist CLOSURE TIME medicine.medical_specialty Ticlopidine Platelet Function Tests medicine.drug_class Iron PERCUTANEOUS CORONARY INTERVENTION PFA-100(TM) INHIBITION STEMI Angioplasty Internal medicine medicine Humans ANGIOPLASTY Aged Aspirin business.industry SURFACES Percutaneous coronary intervention Reproducibility of Results medicine.disease Stainless Steel Surgery Feasibility Studies Tyrosine business Platelet Aggregation Inhibitors iron-induced platelet aggregation |
| Zdroj: | European Journal of Clinical Investigation, 39(2), 103-109. Wiley |
| ISSN: | 0014-2972 |
| DOI: | 10.1111/j.1365-2362.2008.02069.x |
| Popis: | Iron and (stainless) steel are potent platelet aggregation activators, and may be involved in stent thrombosis, a serious complication after intracoronary stenting. Current platelet function tests are suboptimal, because of inappropriate agonists and/or lack of reproducibility. We tested the feasibility and reproducibility of a novel platelet function test using stainless steel as an agonist and compared it with other platelet function tests.In 111 patients with acute ST segment elevation myocardial infarction (STEMI), duplo measurements of iron (Fe)-induced platelet aggregation (FIPA) were performed after clopidogrel, acetylsalicylic acid and/or tirofiban treatment. Within 1 h, citrated blood samples drawn from the femoral sheath before primary percutaneous coronary intervention were added to 100 mg of low carbon steel and after 5 s mixing with vortex, the samples were incubated for 15 min. The ratio between the non-aggregated platelets in the agonist sample and platelets in a reference sample was calculated as the platelet aggregation inhibition.FIPA measurement was highly reproducible (correlation coefficient (R) = 0.942, P This study showed good reproducibility of a novel platelet function test using stainless steel as an agonist and showed correlation with validated platelet function tests. We found that the novel platelet function test is a suitable test for measurement of platelet aggregation inhibition in patients undergoing stenting for STEMI, even when they are taking multiple antiplatelet regimens.Eur J Clin Invest 2009; 39 (2): 103-109. |
| Databáze: | OpenAIRE |
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