Airway responsiveness to hypertonic saline: dose-response slope or PD15?
| Autor: | G. de Meer, Guy B. Marks, Bert Brunekreef, J. C. De Jongste |
|---|---|
| Přispěvatelé: | Virology, Pediatrics, Science in Healthy Ageing & healthcaRE (SHARE) |
| Rok vydání: | 2005 |
| Předmět: |
Male
CHILDREN Severity of Illness Index Gastroenterology chemistry.chemical_compound childhood asthma HISTAMINE Forced Expiratory Volume Odds Ratio Child POPULATION education.field_of_study SCHOOLCHILDREN Eosinophil Granule Proteins respiratory system Prognosis RESPIRATORY SYMPTOMS Anesthesia METHACHOLINE epidemiology Female Bronchial Hyperreactivity medicine.symptom Histamine medicine.drug Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Population Risk Assessment Sensitivity and Specificity Bronchial Provocation Tests provocative dose causing a 15% fall in forced expiratory volume in one second HYPERRESPONSIVENESS Internal medicine Wheeze mental disorders medicine dose-response slope Humans education Asthma Saline Solution Hypertonic Dose-Response Relationship Drug business.industry airway hyperresponsiveness Eosinophil Cationic Protein BRONCHIAL RESPONSIVENESS Odds ratio medicine.disease respiratory tract diseases Hypertonic saline Cross-Sectional Studies chemistry Case-Control Studies Methacholine CHALLENGE Airway business hypertonic saline |
| Zdroj: | European Respiratory Journal, 25(1), 153-158. European Respiratory Society European Respiratory Journal, 25(1), 153-158. EUROPEAN RESPIRATORY SOC JOURNALS LTD |
| ISSN: | 0903-1936 |
| Popis: | The result of airway challenge test with hypertonic saline (HS) is expressed as the dose causing a 15% fall in forced expiratory volume in one second (FEV1; PD15). A noncensored measure, such as the dose-response slope (DRS), allows the evaluation of the risk of asthma for subjects with a fall in FEV115%. The aim of this study was to assess the relationship between airway responsiveness to HS by PD15 or DRS, asthma symptoms and markers of eosinophilic inflammation. Data on current wheeze and airway responsiveness were obtained for 1,107 children (aged 8-13 yrs). Blood eosinophils and serum eosinophil cationic protein (ECP) were assessed in subsets (n = 683 and 485). PD15 was assessed if FEV1 fellor =15%, and the DRS was calculated for all tests. Graphs were constructed to visualise relationships with current wheeze, blood eosinophils and serum ECP. Odds ratios and Spearman's correlation coefficients were calculated to quantify these relationships. Children with features of asthma had lower PD15 and higher DRS, and separation was most pronounced for DRS. Prevalence of current wheeze increased continuously over the entire range of DRS values. Blood eosinophils were significantly higher only for the highest values of DRS. In conclusion, the continuous relationship between airway responsiveness and asthma symptoms is in favour of a noncensored measure of airway responsiveness, such as the dose-response slope. |
| Databáze: | OpenAIRE |
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