The effects of alpha-lipoic acid on diabetic myopathy

Autor: Dubravka Jurisić-Erzen, Romana Jerković, Stanislav Peharec, Danijel Ivanac, Dean Girotto, Gordana Starčević-Klasan
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Alpha-lipoic acid
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Myotoxin
Skeletal muscle
030209 endocrinology & metabolism
Skeletal muscle Regeneration Diabetes mellitus type 1 Alpha-lipoic acid
Antioxidants
Diabetes Mellitus
Experimental
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Atrophy
Muscular Diseases
Diabetes mellitus type 1
Internal medicine
Diabetes mellitus
Animals
Regeneration
Medicine
Rats
Wistar
Myopathy
Thioctic Acid
business.industry
BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences
medicine.disease
Muscle atrophy
Rats
Lipoic acid
Diabetes Mellitus
Type 1
Muscle Fibers
Slow-Twitch
030104 developmental biology
medicine.anatomical_structure
chemistry
Muscle Fibers
Fast-Twitch
medicine.symptom
BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti
business
Intramuscular injection
Zdroj: Journal of Endocrinological Investigation
Volume 41
Issue 2
ISSN: 1720-8386
0391-4097
Popis: Purpose Increased oxidative stress and impaired antioxidant defense are important mechanisms in the pathogenesis of diabetic myopathy. Since diabetes mellitus type 1 decreases muscle regeneration capacity the present study was designed to determine the influence of alpha- lipoic acid (ALA), a potent biological antioxidant, on the process of regeneration of diabetic rat skeletal muscles. Methods 40 Wistar rats were divided into three groups: control (n = 8), untreated diabetic group (n = 16) and ALA treated diabetic group (n = 16). The regeneration process was provoked in streptozotocin- induced diabetic rats in both slow (m.soleus, SOL) and fast (m.extensor digitorum longus, EDL) skeletal muscles by intramuscular injection of myotoxin bupivacaine. At intervals of 10 days and 4 weeks, muscle histochemical and morphometrical analysis (fiber cross areas and fiber type distribution) was performed. Results Changes induced by diabetes are evident in redistribution of muscle fibers and in significant level of atrophy. After 4 weeks of diabetes, glycolytic muscle fibers are dominant in both slow and fast muscles. Muscle atrophy is present in all fiber types except in type I of slow skeletal muscle. Treatment with ALA reduce changes in the morphological properties caused by diabetes mellitus type 1 in slow and fast rat skeletal muscles during the process of regeneration. Conclusion Treatment with lipoic acid during 4 weeks has shown effects on the redistribution of muscle fibers, and can prevent atrophy in slow and fast diabetic muscle
Databáze: OpenAIRE
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