Epidermal hyperproliferation following the induction of microabscesses by leukotriene B4
| Autor: | P.C.M. van de Kerkhof, R.M.Maassen‐De Grood, F.W. Bauer |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pathology
medicine.medical_specialty Leukotriene B4 Human skin Dermatology Biology Skin Diseases Flow cytometry chemistry.chemical_compound Psoriasis Stratum corneum medicine Humans integumentary system medicine.diagnostic_test Epidermis (botany) Hyperplasia medicine.disease Abscess medicine.anatomical_structure chemistry Epidermal hyperproliferation Immunology Epidermis Cell Division |
| Zdroj: | British Journal of Dermatology. 114:409-412 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1986.tb02843.x |
| Popis: | SUMMARY The percentage of non-diploid epidermal cells was determined by flow cytometry following application of leukotriene B4 (LTB4) to human skin. Doses in the range 35–500 ng were shown to cause a marked increase in proliferation, the non-diploid cells reaching a maximum between 72 and 96 h after LTB4 application. No difference was observed between the response of healthy controls and the uninvolved skin of psoriatic patients. We suggest, therefore, that the hyperproliferation is a consequence of the physical disruption of the stratum corneum accompanying the rupture of microabscesses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text