Inkjet printing of transdermal microneedles for the delivery of anticancer agents
| Autor: | Dennis Douroumis, Babur Z. Chowdhry, Nicolaos Scoutaris, Jasim Uddin, Pavlos G. Klepetsanis, Mark R. Prausnitz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Drug
RM Materials science Curcumin Swine media_common.quotation_subject Pharmaceutical Science Nanotechnology Antineoplastic Agents engineering.material Water insoluble Administration Cutaneous High-Energy Shock Waves Polyethylene Glycols Drug Delivery Systems Coating Computer Systems Animals Humans Technology Pharmaceutical Porcine skin Inkjet printing media_common Transdermal Drug Liberation Needles Lipophilicity engineering Polyvinyls Fluorouracil Cisplatin Drug carrier |
| Zdroj: | International journal of pharmaceutics. 494(2) |
| ISSN: | 1873-3476 0378-5173 |
| Popis: | A novel inkjet printing technology is introduced as a process to coat metal microneedle arrays with three anticancer agents 5-fluororacil, curcumin and cisplatin for transdermal delivery. The hydrophilic graft copolymer Soluplus(®) was used as a drug carrier and the coating formulations consisted of drug-polymer solutions at various ratios. A piezoelectric dispenser jetted microdroplets on the microneedle surface to develop uniform, accurate and reproducible coating layers without any material losses. Inkjet printing was found to depend on the nozzle size, the applied voltage (mV) and the duration of the pulse (μs). The drug release rates were determined in vitro using Franz type diffusion cells with dermatomed porcine skin. The drug release rates depended on the drug-polymer ratio, the drug lipophilicity and the skin thickness. All drugs presented increased release profiles (750 μm skin thickness), which were retarded for 900 μm skin thickness. Soluplus assisted the drug release especially for the water insoluble curcumin and cisplatin due to its solubilizing capacity. Inkjet printing has been shown to be an effective technology for coating of metal microneedles which can then be used for further transdermal drug delivery applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect