Impact of age and sex correction on the diagnostic performance of dopamine transporter SPECT
| Autor: | Lars Frings, Ralph Buchert, Helen Schmitz-Steinkrüger, Ivayla Apostolova, Franziska Lara Mathies, Sabine Hellwig, Catharina Lange, Susanne Klutmann, Philipp T. Meyer |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Decreased AUC Binding ratio Age and sex Gastroenterology Parkinsonian syndromes Age Parkinsonian Disorders Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Dopamine transporter Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins biology business.industry Putamen Specific binding ratio Gender General Medicine SPECT biology.protein Female Original Article Sex business Area under the roc curve Tropanes |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-020-05085-2 |
| Popis: | Purpose The specific binding ratio (SBR) of 123I-FP-CIT (FP-CIT) in the putamen decreases with age by about 5% per decade and most likely is about 10% higher in females. However, the clinical utility of age and sex correction of the SBR is still a matter of debate. This study tested the impact of age and sex correction on the diagnostic performance of the putamen SBR in three independent patient samples. Methods Research sample: 207 healthy controls (HC) and 438 Parkinson’s disease (PD) patients. Clinical sample A: 183 patients with neurodegenerative parkinsonian syndrome (PS) and 183 patients with non-neurodegenerative PS from one site. Clinical sample B: 84 patients with neurodegenerative PS and 38 patients with non-neurodegenerative PS from another site. Correction for age and sex of the putamen SBR was based on linear regression in the HC or non-neurodegenerative PS, separately in each sample. The area under the ROC curve (AUC) was used as performance measure. Results The putamen SBR was higher in females compared to males (PPMI: 14%, p p p = 0.361). Age-related decline of the putamen SBR ranged between 3.3 and 10.4% (p ≤ 0.019). In subjects ≥ 50 years, age and sex explained p = 0.025) and in clinical sample A (0.9448 versus 0.9519, p = 0.057). There was a small, non-significant AUC increase in clinical sample B (0.9828 versus 0.9743, p = 0.232). Conclusion These findings do not support age and sex correction of the putaminal FP-CIT SBR in the diagnostic workup of parkinsonian syndromes. This most likely is explained by the fact that the proportion of between-subjects variance caused by age and sex is considerably below the symptom threshold of about 50% reduction in neurodegenerative PS. |
| Databáze: | OpenAIRE |
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