Influence of althesin on coronary blood flow and myocardial oxygen consumption in dogs
| Autor: | D. Patschke, J. W. Gethmann, J. B. Brückner, J. Tarnow, A. Weymar |
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| Rok vydání: | 1974 |
| Předmět: |
Ethylene Oxide
medicine.medical_specialty Cardiac output Castor Oil Time Factors Nitrous Oxide Hemodynamics Blood Pressure Kidney Pregnanediones Surface-Active Agents Dogs Oxygen Consumption Piperidines Heart Rate Internal medicine Coronary Circulation Heart rate medicine Animals Cardiac Output Hydroxysteroids Anesthetics business.industry Myocardium Mean Aortic Pressure Central venous pressure General Medicine Stimulation Chemical Oxygen Drug Combinations Anesthesiology and Pain Medicine Regional Blood Flow Anesthesia Renal blood flow Depression Chemical Injections Intravenous Cardiology Ventricular pressure Anesthesia Intravenous Histamine H1 Antagonists Pharmaceutical Vehicles business Perfusion |
| Zdroj: | Acta anaesthesiologica Scandinavica. 18(1) |
| ISSN: | 0001-5172 |
| Popis: | Glaxo CT 1341 (Althesin) is a new steroid anaesthetic agent dissolved in Cremophor EL. Its influence on hemodynamics was studied in dogs, especially regarding the myocardial contractility, coronary perfusion and myocardial oxygen consumption. The unpremedicated experimental animals were induced with 3 mg/kg piritramide intravenously and normoventilated with a mixture of 70% N2O and 30% O2. All animals were pretreated with a powerful antihistaminic agent (Tavegilr) in order to block reactions to histamine released by Cremophor EL. Five hours later the animals received single intravenous doses of Althesin (1.0 and 2.0 mg/kg). Significant hemodynamic changes (P < 0.025-0.0005) were caused by 2.0 mg/kg. Heart rate, cardiac output and mean pulmonary pressure increased, total peripheral resistance decreased; while central venous pressure, mean aortic pressure and renal blood flow remained unchanged. The resulting increased cardiac work caused a rise in coronary blood flow of 88%, an increased myocardial oxygen consumption of 66% and a decreased coronary resistance of 48%. As coronary arteriovenous difference in oxygen decreased slightly, Althesin has coronary dilatory properties. Myocardial depression was seen in a marked fall of dp/dtmax (the rate of change of the left ventricular pressure) (30%), in a decreased stroke volume and in an increased left ventricular end-diastolic pressure. Maximal hemodynamic responses occurred within the first minute after injection and returned to their preinjection levels after approximately 20 min. A recommended dose in man is 2 mg/kg Althesin Myocardial depression and increased oxygen consumption suggest a cautious use of Althesin in cases of heart and coronary insufficiency. |
| Databáze: | OpenAIRE |
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