Ergot alkaloid inhibition of melanophore stimulating hormone secretion
| Autor: | C.M. Morgan, M.E. Hadley |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Mouse Pituitary Gland Melanophore Stimulating Hormone Chlorpromazine Endocrinology Diabetes and Metabolism Dopamine Pharmacology Biology In Vitro Techniques Cellular and Molecular Neuroscience Mice Endocrinology Ergot alkaloid Internal medicine medicine Animals Secretion Melanocyte-Stimulating Hormones Ergonovine Endocrine and Autonomic Systems Pars intermedia Prolactin Rats Dibenzylchlorethamine Pituitary Gland Female |
| Zdroj: | Neuroendocrinology. 21(1) |
| ISSN: | 0028-3835 |
| Popis: | Ergonovine maleate inhibits melanophore stimulating hormone (MSH) secretion from the incubated frog, rat, and mouse pituitary gland. This ergot alkaloid is partially effective at a concentration as low as 10(-8)M. The inhibitory effect on hormone release is irreversible under the experimental conditions studied. Ergonovine inhibition of MSH secretion is blocked by Dibenamine and chlorpromazine as is dopamine inhibition of MSH secretion. At higher concentrations chlorpromazine as is dopamine inhibition of MSH secretion. Similarities between the cellular mechanisms controlling MSH and prolactin secretion will be discussed. |
| Databáze: | OpenAIRE |
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