Rapidly progressive lupus nephritis and concomitant thrombotic microangiopathy
| Autor: | Ahmed Letaief, Sabria Hacini, Philippe Rouvier, Alain Baumelou, Hassane Izzedine, Chems Gharbi, Edward Bourry |
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| Rok vydání: | 2010 |
| Předmět: |
Nephrology
Adult medicine.medical_specialty Thrombotic microangiopathy Physiology medicine.medical_treatment Lupus nephritis Gastroenterology immune system diseases Adrenal Cortex Hormones Renal Dialysis Physiology (medical) Internal medicine Atypical hemolytic uremic syndrome medicine Humans Lupus Erythematosus Systemic Lupus erythematosus business.industry Thrombotic Microangiopathies Acute Kidney Injury medicine.disease Lupus Nephritis Treatment Outcome Immunology Plasmapheresis Rituximab Female Hemodialysis business medicine.drug |
| Zdroj: | Clinical and experimental nephrology. 14(5) |
| ISSN: | 1437-7799 |
| Popis: | Although uncommon, thrombotic microangiopathy (TMA) is one of the most serious complications in patients with systemic lupus erythematosus. A 30-year-old black woman admitted to our hospital because of fever, fatigue, ‘dark’ urine and rapidly progressive renal failure was found to have systemic lupus erythematous and atypical hemolytic uremic syndrome. Kidney biopsy showed WHO class IV lupus nephritis with crescents and TMA. Hemodialysis was initiated for worsening renal failure. The patient was treated with corticosteroids, monthly pulse intravenous Cyclophosphamide, plasmapheresis and Rituximab on a weekly basis for 4 weeks. The patient’s blood pressure was aggressively controlled using antihypertensive agents. Despite this extensive therapy, she remained dialysis dependent although hematological parameters returned to normal values. |
| Databáze: | OpenAIRE |
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