Comparative Activity of Sisomicin against Mycobacteria In Vitro and against Mycobacterium tuberculosis in Mice
| Autor: | Ilija Pejovic, Frank P. Dunbar, W. Eugene Sanders, Henry Valdez, Robert Cacciatore |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Tuberculosis
medicine.drug_class Antibiotics Tuberculosis Splenic Mycobacterium Microbiology Mycobacterium tuberculosis Mice Isoniazid Animals Immunology and Allergy Medicine Glycosides Tuberculosis Pulmonary biology business.industry Amino Sugars biology.organism_classification medicine.disease Anti-Bacterial Agents carbohydrates (lipids) Infectious Diseases Streptomycin Sisomicin Female Gentamicin Gentamicins business medicine.drug |
| Zdroj: | Journal of Infectious Diseases. 127:720-722 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/127.6.720 |
| Popis: | Activity of sisomicin was assayed against 45 clinical isolates of mycobacteria in vitro. Sisomicin was as active as streptomycin or gentamicin against strains susceptible to each of the three drugs. Sisomicin inhibited growth of strains that were highly resistant to isoniazid or streptomycin, or both. Sisomicin and gentamicin were weakly tuberculostatic and less efficacious than equivalent dosages of streptomycin in treatment of mice infected with Mycobacterium tuberculosis. Because these drugs are highly active against mycobacteria in vitro and because their action in other infected species is unknown, physicians should be alert to the possibility that their short-term investigative or therapeutic use for gramnegative bacillary infections may impede recovery of mycobacteria from clinical specimens. |
| Databáze: | OpenAIRE |
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