Study on the dynamic change law and correlation between CT imaging manifestations and cellular immunity of 2019 novel coronavirus disease
| Autor: | Bingqian Zhang, Guozhong Zhou, Guanzuan Wu, Xuedong Sun, Minxia Yang, Yanan Huang, Lujiao Chen, Sang-Ying Lv, Minhui Li, Haijia Mao, Mingzhu Wei, Li Zhao, Zhenhua Zhao, Bo Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cellular immunity medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral Disease Gastroenterology Group A Group B 030218 nuclear medicine & medical imaging Correlation 03 medical and health sciences Betacoronavirus 0302 clinical medicine Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Lung Pandemics Computed tomography Aged Retrospective Studies Immunity Cellular business.industry SARS-CoV-2 COVID-19 Middle Aged ROC Curve Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Female Original Article Ct imaging business Coronavirus Infections Tomography X-Ray Computed Laboratories |
| Zdroj: | Japanese Journal of Radiology |
| ISSN: | 1867-108X 1867-1071 |
| DOI: | 10.1007/s11604-020-00997-3 |
| Popis: | Purpose To explore the dynamic changes and correlation between CT imaging manifestations and cellular immunity of COVID-19. Materials and methods This retrospective review analyzed 23 patients with COVID-19, including 13 males and 10 females aged 27–70 years, with an average age of 48 years. Patients were divided into two groups: group A with 11 critical-severe patients, and group B with 12 common-mild patients. Clinical, laboratory, and radiological data were collected and analyzed. Results LYM, LYM (%), CD3+, CD4+, and CD8+ decreased, while NEU (%), CRP, and CT scores increased in all patients, WBC in group A increased. In group A, on day 10–12 after disease onset, CT scores and CRP reached the highest point, and day 13–15 LYM, LYM (%) reached the lowest but NEU (%) and WBC reached the highest, CD3+, CD4+ and CD8+ were at the lowest on day 10–15. In group B, on day 7–9, CT scores, NEU (%) and CRP reached the peak, but LYM, LYM (%), CD3+, CD4+ and CD8+ reached the lowest. In all patients, CT scores had a significantly negative correlation with CD3+, CD4+, CD8+, LYM (%), and LYM (p = 0.001, r = − 0.797; p = 0.008, r = − 0.698; p = 0.002, r = − 0.775; p |
| Databáze: | OpenAIRE |
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