A Simple and Low-Cost Method for Fabrication of Polydimethylsiloxane Microfludic Chips
| Autor: | Zhifu Yin, Biyao Zhang, Xue Yang, Linlin Sun, Likang Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fabrication
Microchannel Laser ablation Materials science Polydimethylsiloxane Microfluidics Biomedical Engineering Bioengineering Nanotechnology 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics chemistry.chemical_compound chemistry Cleanroom General Materials Science Laser power scaling 0210 nano-technology Leakage (electronics) |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 21:5635-5641 |
| ISSN: | 1533-4880 |
| Popis: | The conventional fabrication methods for enrichment microfluidic devices require cleanroom, which are costly and time-consuming. Developing a facile and low-cost method to fabricate microfluidic chips could stimulate the progress of the applications of those chips. Here, we present an easy method for fabrication of a complete PDMS (Polydimethylsiloxane) microfluidic chip used for ion and protein enrichment. The method consists of three main fabrication steps: PDMS microchannels ablation by co2 laser, nation membrane deposition, and oxygen plasma assist bonding under pressure. To fabricate a desired microchannel, the laser ablation parameters, containing laser power and ablation speed, were analyzed. The parameters for oxygen plasma assist bonding were also investigated to improve the bonding quality of the chips (low dimension loss and high bonding strength). The following Rhodamine B enrichment tests demonstrate that the presented method allows fabrication of microfluidic chips with precise dimensions and leakage free. |
| Databáze: | OpenAIRE |
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