Hemostatic abnormalities in inflammatory bowel disease
| Autor: | Francesco Tonelli, Demenico Prisco, Agatina Alessandrello Liotta, Isabella Ilari, Elena Chiarantini, Rosa Valanzano, Rosanna Abbate, Sandra Fedi, Anna Paola Cellai |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Fibrinogen Inflammatory bowel disease Protein S Crohn Disease Fibrinolysis medicine Humans Blood Coagulation Aged Aged 80 and over Hemostasis Crohn's disease biology business.industry Antithrombin Thrombosis Hematology Middle Aged medicine.disease Factor XIII digestive system diseases Immunology Antibodies Antiphospholipid biology.protein Colitis Ulcerative Female business Plasminogen activator medicine.drug |
| Zdroj: | Thrombosis Research. 82:137-146 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(96)00060-6 |
| Popis: | Patients affected by inflammatory bowel disease (IBD) frequently suffer from thromboembolic events. Aims of this study were to investigate hemostatic system and the presence of antiphospholipid antibodies (aPL) in IBD patients. Forty-one patients affected by Crohn's disease (CD) and 19 by ulcerative colitis (UC) were studied, compared to 40 healthy control subjects. Platelet count (PLT), PT, aPTT, fibrinogen (Fib), prothrombin fragment F1+2, antithrombin (AT), protein C (PC), protein S (PS), factor XIII (FXIII), plasminogen (PLG), plasminogen activator inhibitor (PA1), spontaneous platelet aggregation in platelet-rich plasma (PRP-SPA) and in whole blood (WB-SPA), and antiphospholipid antibodies (aPL) were evaluated. PLT, Fib, F1+2 and WB-SPA were significantly increased in IBD patients (p at least0.05) both in active and inactive phases; aPL positivity was more frequent (p0.05) and FXIII was significantly decreased (p0.05) in comparison to control subjects. The thrombophilic state of IBD patients is not related to the degree of activity of the disease or to previous thrombotic events; aPL express the immunological alterations connected with IBD and are not the main cause of thrombotic events. |
| Databáze: | OpenAIRE |
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