Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi

3)2-O-lauryl-alpha-L- rhamnopyranose(1-->3)2,4-di-O-acetyl/lauryl-6-deoxy-alpha-L-glucopyranos e]. The type of analyses previously applied to the glycopeptidolipids of M. avium combined with fast atom bombardment mass spectrometry allowed the recognition of other variants of this structure in other strains of M. xenopi: [formula: see text] in which the monosaccharide is 2-O-acetyl-3-O-CH3-6-deoxy-alpha-L-talopyranose or 3-O-CH3-6-deoxy-alpha-L-talopyranose, and the disaccharide is 4-O-octanoyl(or decanoyl)-alpha-L- rhamnopyranose(1-->3)2-O-lauryl-alpha-L-rhamnopyranose or alpha-L-rhamnopyranose(1-->3)2-O-lauryl-alpha-L-rhamnopyranose. Recognition of serine-containing glycopeptidolipids substituted in one case with a tetrasaccharide and in another case with a disaccharide unit implies that M. xenopi, an important opportunistic pathogen, exists as a serocomplex in nature. -->

ISSN:	1520-4995 0006-2960
DOI:	10.1021/bi00052a043
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df79444bc01dd9ac60f7a20be6f1bd57 https://doi.org/10.1021/bi00052a043
Přírůstkové číslo:	edsair.doi.dedup.....df79444bc01dd9ac60f7a20be6f1bd57
Autor:	Howard R. Morris, Becky Rivoire, Michael R. McNeil, Kay-Hooi Khoo, Anne Dell, Gurdyal S. Besra, Patrick J. Brennan
Rok vydání:	1993
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Molecular Sequence Data Disaccharide Spectrometry Mass Fast Atom Bombardment Biochemistry Gas Chromatography-Mass Spectrometry Mycobacterium Epitopes chemistry.chemical_compound Opportunistic pathogen A-tetrasaccharide Carbohydrate Conformation Tetrasaccharide Mycobacterium avium complex Amino Acid Sequence Amino Acids Mycobacterium xenopi Antigens Bacterial Molecular Structure biology Glycopeptides Fast atom bombardment biology.organism_classification chemistry Carbohydrate conformation Glycolipids
Zdroj:	Biochemistry. 32:347-355
ISSN:	1520-4995 0006-2960
DOI:	10.1021/bi00052a043
Popis:	The highly antigenic surface glycolipids of serovars of the Mycobacterium avium complex are glycopeptidolipids of the general structure [formula: see text] However, it has recently been shown [Riviere, M., & Puzo, G. (1991) J. Biol. Chem. 266, 9057-9063; Riviere, M., & Puzo, G. (1992) Biochemistry 31, 3575-3580] that the characteristic glycopeptidolipid of a strain of Mycobacterium xenopi is of the structure [formula: see text] [monosaccharide, 3-O-CH3-6-deoxy-alpha-L-talopyranose; tetrasaccharide, 2,3,4-tri-O-CH3-alpha-L-rhamnopyranose(1-->3)2-O-lauryl-alpha-L- rhamnopyranose(1-->3)2,4-di-O-acetyl/lauryl-6-deoxy-alpha-L-glucopyranos e]. The type of analyses previously applied to the glycopeptidolipids of M. avium combined with fast atom bombardment mass spectrometry allowed the recognition of other variants of this structure in other strains of M. xenopi: [formula: see text] in which the monosaccharide is 2-O-acetyl-3-O-CH3-6-deoxy-alpha-L-talopyranose or 3-O-CH3-6-deoxy-alpha-L-talopyranose, and the disaccharide is 4-O-octanoyl(or decanoyl)-alpha-L- rhamnopyranose(1-->3)2-O-lauryl-alpha-L-rhamnopyranose or alpha-L-rhamnopyranose(1-->3)2-O-lauryl-alpha-L-rhamnopyranose. Recognition of serine-containing glycopeptidolipids substituted in one case with a tetrasaccharide and in another case with a disaccharide unit implies that M. xenopi, an important opportunistic pathogen, exists as a serocomplex in nature.
Databáze:	OpenAIRE
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