Therapeutic drug monitoring of daptomycin: a retrospective monocentric analysis
| Autor: | Natascia Corti, Oliver Senn, Daniel Müller, Gerd A. Kullak-Ublick, Claudine Reiber |
|---|---|
| Přispěvatelé: | University of Zurich, Corti, Natascia |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male 11035 Institute of General Practice medicine.medical_specialty Adolescent medicine.medical_treatment Cmax Urology Renal function 610 Medicine & health Pharmacology law.invention Cmin chemistry.chemical_compound Daptomycin law polycyclic compounds Medicine Humans 2736 Pharmacology (medical) Pharmacology (medical) Renal replacement therapy Aged Retrospective Studies 10038 Institute of Clinical Chemistry Aged 80 and over Creatinine medicine.diagnostic_test business.industry Middle Aged Intensive care unit Anti-Bacterial Agents Renal Replacement Therapy 3004 Pharmacology chemistry Therapeutic drug monitoring 10199 Clinic for Clinical Pharmacology and Toxicology Linear Models Female Drug Monitoring business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | Background: Daptomycin dose is adjusted to body weight and renal function and is usually not guided by therapeutic drug monitoring (TDM). Daptomycin plasma concentration measurement was established at our institution in January 2009 and is now increasingly being used. The aim of this study was to describe and characterize variability in daptomycin exposure during routine clinical therapy. Methods: We collected daptomycin plasma concentrations that were measured at our institution during the period January 2009-July 2012. Additional clinical and demographic data and their association with daptomycin exposure was tested by a multilevel linear regression analysis. Results: A total of 332 daptomycin plasma concentrations were determined in 86 patients. 66% (n=218) of all determinations were trough concentrations (Cmin) and 34% (n=114) were peak concentrations (Cmax). Cmin ranged 2-68mg/L (median 16.7mg/L) and Cmax 20-236mg/L (median 66.2mg/L). A significant positive association of total dose, albumin, creatinine, and a significant negative association of dose interval and intermittent haemodialysis with Cmin was found in the regression analysis. Total dose and Intensive Care Unit (ICU)_-stay was significantly associated with Cmax (P |
| Databáze: | OpenAIRE |
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