Tissue Specificity of the Epididymal Androgen Dependent Phospholipase A
| Autor: | Bente Beck |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
endocrine system medicine.medical_specialty medicine.drug_class Urology Endocrinology Diabetes and Metabolism Biology Phospholipases A chemistry.chemical_compound Prostate Internal medicine medicine Animals Testosterone Castration Epididymis Kidney Phospholipase A urogenital system Lysophosphatidylcholines Androgen Rats Cytosol Endocrinology medicine.anatomical_structure Reproductive Medicine chemistry Organ Specificity Phospholipases |
| Zdroj: | International Journal of Andrology. 3:349-362 |
| ISSN: | 1365-2605 0105-6263 |
| DOI: | 10.1111/j.1365-2605.1980.tb00124.x |
| Popis: | The effect of androgens on phospholipase A in the rat epididymis, liver, heart, kidney, prostate and epididymal fat pad has been investigated both in the cytosol and in a postmitochondrial partiulate cell fraction. In both cell fractions, phospholipase A activity was 10–15 times higher in the cauda epididymidis than in the other organs, including the caput epididymidis, while the corpus showed an intermediate activity. In the cauda and corpus, castration reduced phospholipase A activity in both subcellular fractions to the same level as found in the other organs, and testosterone supplementation restored the enzyme activity. No evidence of a similar androgen controlled phospholipase A was found in any other tissue examined, including the prostate. |
| Databáze: | OpenAIRE |
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