Micronutrient concentrations in respiratory syncytial virus and human metapneumovirus in Yemeni children
| Autor: | Bernard J. Brabin, N. Al-Aghbari, Najla Al-Sonboli, C. A. Hart, Z Atef, E. Roberts, Greg Harper, A. Al-Aryani, Alan Shenkin, Luis E. Cuevas |
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| Přispěvatelé: | Paediatric Infectious Diseases / Rheumatology / Immunology |
| Rok vydání: | 2009 |
| Předmět: |
Male
Yemen Paramyxoviridae viruses Respiratory Syncytial Virus Infections Virus Pneumovirinae Selenium Human metapneumovirus Medicine Humans Vitamin E Metapneumovirus Micronutrients Prospective Studies Mononegavirales Vitamin A Paramyxoviridae Infections biology business.industry Infant Newborn virus diseases Infant Pneumovirus respiratory system Micronutrient biology.organism_classification Virology respiratory tract diseases Zinc C-Reactive Protein Pediatrics Perinatology and Child Health Female business Copper |
| Zdroj: | Annals of tropical paediatrics, 29(1), 35-40. Maney Publishing |
| ISSN: | 1465-3281 0272-4936 |
| Popis: | BACKGROUND: Acute respiratory infections (ARI) cause significant childhood mortality. Nutritional homeostasis, particularly micronutrient levels, is important in modulating response to infection. More information is required regarding micronutrient levels in ARI viral infections, especially newly identified viruses such as human metapneumovirus (HMPV). AIM: To describe zinc, copper, selenium and vitamins A and E concentrations in children with respiratory syncytial virus (RSV) and/or HMPV in relation to levels of C-reactive protein (CRP). METHODS: The presence of RSV/HMPV in nasopharyngeal aspirates (NPA) was identified in 246 children using RTPCR. Zinc, copper, selenium and vitamins A and E concentrations were measured using inductive coupled plasma mass spectrometry and high performance liquid chromatography. RESULTS: 183 children had RSV, 39 had HMPV and 24 were co-infected. Zinc concentrations were lower in children with HMPV than in children with RSV or RSV/HMPV co-infection. Copper concentrations were lower in children with RSV than in children with RSV/HMPV or HMPV and zinc/copper ratios were lower in children with HMPV/RSV or RSV than in children with HMPV alone. Retinol and a alpha-tocopherol were lower in children with RSV than in children with HMPV. Most children had low selenium concentrations. Children with RSV and raised CRP (>5 mg/L) had higher copper and lower zinc/copper ratios than those with low CRP ( |
| Databáze: | OpenAIRE |
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