Comparison of the Diagnostic Value of Immunochromatography Kits in Corona Virus Disease 2019 Patients: A Prospective Pilot Study
| Autor: | Masakata Yoshioka, Kumi Akita, Masahiko Uzura, Satoshi Takeda, Kunihiro Mashiko, Akihiro Sekine, Toshiya Mitsunaga, Yutaka Seki, Ippei Suzuki, Syunsuke Mashiko |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
IgM biology Coronavirus disease 2019 (COVID-19) IgG business.industry immunochromatography kit Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Large population COVID-19 Virus diseases medicine.disease_cause Gastroenterology antibody Internal medicine biology.protein medicine Original Research Article Symptom onset Antibody business Antibody detection Coronavirus |
| Zdroj: | JMA Journal |
| ISSN: | 2433-3298 2433-328X |
| DOI: | 10.31662/jmaj.2020-0084 |
| Popis: | Introduction The spread of coronavirus 2019 (COVID-19) is a serious problem all over the world. Several immunochromatography kits of the antibody for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed, but it is still unclear which kits have high diagnostic value. This study aims to evaluate the accuracy rate for antibody detection of each immunochromatography kit and reveal which kit has a high diagnostic value for antibody detection. Methods This study was carried out between 1 August 2020 and 14 October 2020 at the Association of EISEIKAI Medical and Healthcare Corporation Minamitama Hospital. Patients diagnosed with COVID-19 and approximately 30 days after symptom onset were included as the positive group. The serum SARS-CoV-2 antibodies were analysed using seven immunochromatography kits. Results Twenty samples (Positive group: 10 patients, Negative group: 10 healthy medical workers) were included in this study. The median age of the patients was 44 years, and the median duration from symptom onset was 30.5 days in the positive group. The accuracy rates for IgM/IgG detection were: 90.0%/100% in Kit A; 50.0%/95.0% in Kit B; 55.0%/65.0% in Kit C; 60.0%/55.0% in Kit D; 50.0%/80.0% in Kit E; 80.0%/90.0% in Kit F; and 90.0%/100% in Kit G. Conclusions Our study showed that there is a variation of accuracy rates between immunochromatography kits for antibodies of SARS-CoV-2. COVID-19 IgG/IgM RAPID TEST CASSETTE (Hangzhou Biotest Biotech Co., Ltd., China) and Nadal COVID-19 IgG/IgM Rapid Test (BioServUK Ltd., UK: United Kingdom) have high accuracy rates for both IgM and IgG detection. Evidence from large population studies of immunochromatography kits is needed to clarify the details of diagnostic value for SARS-CoV-2. |
| Databáze: | OpenAIRE |
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