Neurodegenerative Diseases: The Value of Early Predictive End Points
Autor: | Sarah, Janicki Hsieh, Zoi, Alexopoulou, Nitin, Mehrotra, Arie, Struyk, S Aubrey, Stoch |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Clinical Pharmacology & Therapeutics. 111:835-839 |
ISSN: | 1532-6535 0009-9236 |
Popis: | Use of early predictive biomarkers of neurodegenerative disease in phase I clinical trials may improve the translation of novel drug therapies from preclinical development through late-stage studies. This article provides a categorical summary of promising biomarker approaches or clinical end points in molecular, cellular, metabolic, electrophysiological, or clinical function that can be used to predict or quantify the progression of neurodegenerative disorders and guide program support. |
Databáze: | OpenAIRE |
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