Gender-Dependent Effect of Maternal Methyl-Enriched Diet on the Expression of Genetic Absence Epilepsy and Comorbid Depression in Adult Offspring of WAG/Rij Rats
| Autor: | A. V. Gabova, Alla Shatskova, K. Yu. Sarkisova, Ekaterina Fedosova |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Offspring Epileptogenesis General Biochemistry Genetics and Molecular Biology Epigenesis Genetic 03 medical and health sciences chemistry.chemical_compound Epilepsy 0302 clinical medicine Pregnancy Internal medicine Genetic model Medicine Choline Animals Humans Epigenetics Vitamin B12 Depression (differential diagnoses) 0303 health sciences Sex Characteristics General Immunology and Microbiology business.industry Depression 030302 biochemistry & molecular biology General Medicine Maternal Nutritional Physiological Phenomena medicine.disease Rats Disease Models Animal Endocrinology chemistry Epilepsy Absence Female General Agricultural and Biological Sciences business 030217 neurology & neurosurgery |
| Zdroj: | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 494(1) |
| ISSN: | 1608-3105 |
| Popis: | In the present study it has been shown for the first time that maternal methyl-enriched diet (choline, betaine, folic acid, vitamin B12, L-methionine, zinc) during perinatal period reduces the expression of genetic absence epilepsy and comorbid depression in adult offspring of WAG/Rij rats. This beneficial effect was more pronounced in males compared with females. It is assumed that epigenetic modifications induced by maternal methyl-enriched diet in the offspring at the early stages of ontogenesis might be a possible mechanism underlying the correction of genetically-based pathologic phenotype in WAG/Rij rats. Results suggest that methyl-enriched diet during perinatal period can be potentially used for mitigation or prevention epileptogenesis and depression-like comorbid disorders in people genetically predisposed to absence epilepsy. |
| Databáze: | OpenAIRE |
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