Randomised study of prophylactic parenteral sulbactam/ampicillin and cephazolin in biliary surgery: Significant benefit in jaundiced patients
| Autor: | R.C.B. Slack, J. A. Jones, David L. Morris, R.J.M. Phillips, G.I. Andrews, J D Harrison |
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| Rok vydání: | 1989 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty medicine.drug_class Premedication Antibiotics Jaundice Microbial Sensitivity Tests law.invention Sepsis Random Allocation Postoperative Complications Randomized controlled trial law Ampicillin Cefazolin medicine Humans Cholecystectomy business.industry General Medicine Sulbactam biochemical phenomena metabolism and nutrition medicine.disease Surgery Infectious Diseases Anesthesia Injections Intravenous Wound Infection Biliary Tract Surgery Sulbactam ampicillin medicine.symptom business medicine.drug |
| Zdroj: | Journal of Hospital Infection. 13:261-266 |
| ISSN: | 0195-6701 |
| Popis: | Two hundred consecutive patients undergoing biliary-tract surgery were entered into a randomized trial of prophylactic single dose cephazolin or sulbactam/ampicillin. There was no overall difference in the infection rates between the two antibiotic groups, but in the group of patients with jaundice there was an excess of wound infections in the cephazolin group compared to the sulbactam/ampicillin group (35% vs. 14%). We conclude that sulbactam/ampicillin is a satisfactory prophylactic agent for use in biliary-tract surgical sepsis, and that it may be superior to cephazolin in jaundiced patients. |
| Databáze: | OpenAIRE |
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