Effect of external irradiation on the gastrointestinal absorption of uranium and neptunium in rats
| Autor: | I. Dublineau-Naud, F. Paquet, P. Houpert |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
inorganic chemicals
Absorption (pharmacology) Male chemistry.chemical_element complex mixtures Excretion Neptunium Rats Sprague-Dawley Feces Pharmacokinetics Animals Radiology Nuclear Medicine and imaging Tissue Distribution Irradiation Radionuclide Radiological and Ultrasound Technology Chemistry Radiochemistry technology industry and agriculture Uranium Plutonium Rats Specific Pathogen-Free Organisms Intestinal Absorption Gamma Rays Digestive System Whole-Body Irradiation Nuclear chemistry |
| Zdroj: | International journal of radiation biology. 77(3) |
| ISSN: | 0955-3002 |
| Popis: | Purpose : The gastrointestinal absorption and systemic distribution of uranium and neptunium were determined after external gamma irradiation. Materials and methods : Rats were exposed to a single whole-body dose of gamma radiation (6 Gy; 0.75 Gy.min -1) . Three days after irradiation they were orally and/or intravenously contaminated with 100 μ g.kg -1 uranium or 3 kBq.kg -1 neptunium. The gastrointestinal absorption and organ distribution of both radionuclides were measured 6 days after irradiation. Results : External irradiation increased the intestinal transit time of uranium and neptunium but had no effect on their gastrointestinal absorption. The average fractional absorption was determined to be 0.93 and 0.98% (uranium) and 4.7 and 4.8% (neptunium) for the irradiated and non-irradiated rats respectively. The excretion of uranium and neptunium was not affected by the irradiation. Conclusion : A 6 Gy whole-body irradiation (gamma; 0.75 Gy.min -1) did not affect the absorption of uranium and neptunium... |
| Databáze: | OpenAIRE |
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