Fluorocholine PET/CT in Patients with Prostate Cancer: Initial Experience
| Autor: | Hubert John, Thomas F. Hany, Gerrit Westera, Tibor Cservenyak, Daniel T. Schmid, Roland Zweifel, Gerhard W. Goerres, Gustav K. von Schulthess |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Fluorine Radioisotopes medicine.medical_specialty Bone Neoplasms Adenocarcinoma Sensitivity and Specificity Prostate cancer Prostate Image Interpretation Computer-Assisted medicine Humans Tissue Distribution Radiology Nuclear Medicine and imaging In patient Lymph node Aged Neoplasm Staging Pelvic Neoplasms Aged 80 and over PET-CT medicine.diagnostic_test business.industry Prostatic Neoplasms Middle Aged Image Enhancement Institutional review board medicine.disease Quaternary Ammonium Compounds medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Tomography Radiology Neoplasm Recurrence Local Tomography X-Ray Computed Nuclear medicine business |
| Zdroj: | Radiology. 235:623-628 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2352040494 |
| Popis: | Institutional review board approval and written informed consent were obtained. Patients with newly diagnosed prostate cancer and patients suspected of having recurrent prostate cancer were prospectively evaluated with fluorine 18 fluorocholine (FCH) combined in-line positron emission tomography (PET) and computed tomography (CT). In 19 patients (mean age, 67 years +/- 8; range, 57-85 years), standardized uptake values of FCH in 17 different tissues were determined by using volumes of interest. In nine patients evaluated at initial staging, histologic findings of the resected prostate were compared to FCH uptake. Only small variations of physiologic tracer accumulation were measured in all organs but the kidneys. Differentiation of benign hyperplasia from cancerous prostate lesions was not possible with FCH PET/CT. However, in patients with recurrent prostate cancer, FCH PET/CT is a promising imaging modality for detecting local recurrence and lymph node metastases. |
| Databáze: | OpenAIRE |
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