Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
| Autor: | Alexandra Dimova, Robert C. Verdonk, Povilas Ignatavicius, Laureen Erichson-Kirst, Sebastian Beer, Lucas Ilzarbe, Hanna Sternby, Jonas Rosendahl, Mariella Mahle, Harald Busse, Peeter Koiva, Walter A. Wohlgemuth, Richard Brill, Franz Stangl, Nicolas Linder, Thomas L. Bollen, Anne K. Penttilä, Sara Regnér, Patrick Michl, Vijay P. Singh |
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| Přispěvatelé: | Clinicum, Department of Surgery, HUS Abdominal Center, University of Zurich, Rosendahl, Jonas |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
PREDICTION Adipose tissue severity Gastroenterology Severity of Illness Index 0302 clinical medicine Odds Ratio visceral adipose tissue Prospective cohort study mean muscle attenuation RISK Muscles NECROSIS Middle Aged Radiographic Image Enhancement medicine.anatomical_structure Oncology muscle mass 030220 oncology & carcinogenesis OBESITY Body Composition Acute pancreatitis SKELETAL-MUSCLE 2730 Oncology 030211 gastroenterology & hepatology Female Muscle tissue Adult medicine.medical_specialty Subcutaneous Fat 610 Medicine & health Intra-Abdominal Fat 03 medical and health sciences Internal medicine medicine Humans 2715 Gastroenterology COMPUTED-TOMOGRAPHY 10217 Clinic for Visceral and Transplantation Surgery Aged Receiver operating characteristic business.industry MORTALITY Odds ratio medicine.disease Obesity Confidence interval BODY-MASS INDEX Pancreatitis ROC Curve FAT 3121 General medicine internal medicine and other clinical medicine business Tomography X-Ray Computed |
| Popis: | Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. Objective The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p-values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61-10.36, p-value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis. Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP. |
| Databáze: | OpenAIRE |
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