Methotrexate inhibits the leukotriene B4 induced intraepidermal accumulation of polymorphonuclear leukocytes
| Autor: | P.C.M. Kerkhof, F.W. Bauer, R.M.Maassen‐De Grood |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Neutrophils Leukotriene B4 Uninvolved skin Dermatology chemistry.chemical_compound Leukocytes medicine Humans Psoriasis business.industry Significant difference Penetration (firestop) Middle Aged medicine.disease Chemotaxis Leukocyte Methotrexate chemistry Immunology Female Epidermis business Infiltration (medical) medicine.drug |
| Zdroj: | British Journal of Dermatology. 113:251a-255a |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1985.tb02075.x |
| Popis: | SUMMARY The penetration of polymorphonuclear leukocytes (PMNs) into the epidermis following topical application of leukotriene B4 was assessed in the clinically uninvolved skin of psoriatic patients treated with methotrexate and of psoriatic patients without treatment, and in normal controls. Inhibition of PMN infiltration was observed in those patients treated with methotrexate while there was no significant difference between untreated psoriatic patients and normal controls. |
| Databáze: | OpenAIRE |
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