Visual and semiautomated evaluation of epileptogenicity in focal cortical dysplasias - An intracranial EEG study

Autor: Tim Wehner, Fabrice Bartolomei, Roman Rodionov, Hajo M. Hamer, Beate Diehl, Ivan Valente, Stephanie Gollwitzer, Catherine Scott, Laura Mantoan Ritter
Přispěvatelé: Institute of Neurology, Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute of Neurology [London], University College of London [London] (UCL), King‘s College London
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Pathology
Subdural Space
Electroencephalography
Stereoelectroencephalography
Cohort Studies
03 medical and health sciences
Behavioral Neuroscience
Epilepsy
Young Adult
0302 clinical medicine
Seizures
medicine
Humans
Telemetry
Epilepsy surgery
Ictal
Subdural space
Electrocorticography
Retrospective Studies
medicine.diagnostic_test
[SCCO.NEUR]Cognitive science/Neuroscience
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Electrodes
Implanted
Malformations of Cortical Development
030104 developmental biology
medicine.anatomical_structure
Treatment Outcome
Neurology
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Female
Neurology (clinical)
Radiology
Psychology
030217 neurology & neurosurgery
Zdroj: Epilepsy & Behavior
Epilepsy & Behavior, [San Diego CA]: Elsevier B.V., 2016, 58, pp.69-75. ⟨10.1016/j.yebeh.2016.03.009⟩
Epilepsy & Behavior, 2016, 58, pp.69-75. ⟨10.1016/j.yebeh.2016.03.009⟩
ISSN: 1525-5050
1525-5069
DOI: 10.1016/j.yebeh.2016.03.009⟩
Popis: International audience; Introduction: The aim of the study was the evaluation of the added value of depth to subdural electrodes in delineating epileptogenicity of focal cortical dysplasias (FCDs) and to test the Epileptogenicity Index (EI) in this setting. Material and methods: Fifteen patients with FCD underwent iEEG with subdural and depth electrodes. Visual/EI analysis was performed in up to three habitual seizures per patient. Results: Visual analysis: Grid onset seizures (n=10) started in electrodes overlying the lesion in 7 and remote from it in 3 cases. Depth onset seizures (n=7) affected only intralesional contacts in 4, intra-and extralesional in 2, and exclusively extralesional in 1 patient. Seizures started in depth and grid contacts simultaneously in 2 cases. EI analysis: The EI completely confirmed visual localization of seizure onset in 8 cases and depicted ictal onset-time accurately in 13. Beta/gamma ictal patterns were most reliably captured. Impact on surgical decision: Resection outline differed from MRI lesion in 7 patients based on grid and in three based on depth electrode information. Discussion: In FCD, seizures can be generated within gyral/deep tissue appearing normal on imaging. Conclusion: Investigating FCD with subdural and depth electrodes is efficient to outline the seizure onset zone. The EI is a helpful additional tool to quantify epileptogenicity. Specific ictal patterns are prerequisite for reliable results. (C) 2016 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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