Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor

Autor:	Lin-Fa Wang, Patricia Soteropoulos, Nigel J. Temperton, Efstathios S. Giotis, Saleena Ghanny, George Carnell, Michael A. Skinner, Erik F. Young, Wendy S. Barclay
Rok vydání:	2019
Předmět:	Microbiology (medical) Virus genetics viruses Immunology Orthomyxoviridae Applied Microbiology and Biotechnology Microbiology Virus Madin Darby Canine Kidney Cells 03 medical and health sciences Dogs 1108 Medical Microbiology A VIRUS Chiroptera Zoonoses Genetics HLA-DR TOPOLOGY Animals Humans Receptor 030304 developmental biology QR355 0303 health sciences MHC class II Science & Technology biology 030306 microbiology HLA-DR Antigens Cell Biology Virus Internalization Microarray Analysis biology.organism_classification Virology REVEAL Viral Tropism HEK293 Cells biology.protein Tissue tropism Receptors Virus Life Sciences & Biomedicine Neuraminidase 0605 Microbiology
Zdroj:	Nature Microbiology. 4:2035-2038
ISSN:	2058-5276
DOI:	10.1038/s41564-019-0517-3
Popis:	Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6a6fde9cc7336b38b3b2b2b2e91a15 https://doi.org/10.1038/s41564-019-0517-3 Zobrazit plný text záznamu Full text from SpringerLink