Diabetes alters the association between high-density lipoprotein subfractions and carotid intima-media thickness: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Autor: Krishnaji R. Kulkarni, Alessandra C. Goulart, Peter P. Toth, Steven R. Jones, Márcio Sommer Bittencourt, Michael J. Blaha, Itamar S. Santos, Giuliano Generoso, Raul D. Santos, Paulo A. Lotufo, Isabela M. Benseñor
Rok vydání: 2018
Předmět:
Adult
Carotid Artery Diseases
Male
medicine.medical_specialty
Longitudinal study
Endocrinology
Diabetes and Metabolism
Negative association
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Predictive Value of Tests
Risk Factors
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Internal Medicine
Humans
Medicine
Longitudinal Studies
030212 general & internal medicine
Adult health
Aged
Dyslipidemias
business.industry
Cholesterol
HDL
Confounding
Middle Aged
Prognosis
medicine.disease
Vertical auto profile
Cross-Sectional Studies
Endocrinology
Intima-media thickness
chemistry
Female
lipids (amino acids
peptides
and proteins)
Cardiology and Cardiovascular Medicine
business
Biomarkers
Brazil
Zdroj: Diabetes and Vascular Disease Research. 15:541-547
ISSN: 1752-8984
1479-1641
DOI: 10.1177/1479164118788080
Popis: Introduction: High-density lipoprotein cholesterol comprises a group of heterogeneous subfractions that might have differential effects on atherosclerosis. Moreover, prior investigations suggest that the presence of diabetes (T2D) modifies the impact of some subfractions on atherosclerosis. In this study, we aimed to evaluate the association between high-density lipoprotein cholesterol subfractions and carotid intima-media thickness in the baseline assessment of the Brazilian Longitudinal Study of Adult Health participants from the São Paulo investigation centre. Methods: We evaluated 3930 individuals between 35 and 74 years without previous cardiovascular disease not using lipid-lowering drugs. High-density lipoprotein cholesterol subfractions (HDL2-C and HDL3-C) were measured by vertical ultracentrifugation (vertical auto profile). The relationship between each high-density lipoprotein cholesterol subfraction and carotid intima-media thickness was analysed by multiple linear regression models. Results: Total high-density lipoprotein cholesterol, as well as HDL2-C and HDL3-C, was negatively associated with carotid intima-media thickness after adjustment for demographic data (all p 2-C/HDL3-C ratio showed a negative association with carotid intima-media thickness in participants with T2D ( p = 0.032), even after fully controlling for confounding variables, including total high-density lipoprotein cholesterol. Conclusion: HDL2-C, HDL3-C and HDL2/HDL3-C ratio are inversely associated with carotid intima-media thickness after adjustment for traditional risk factors. Association of the HDL2-C/HDL3-C ratio is modified by the presence of diabetes, being more pronounced in diabetic individuals.
Databáze: OpenAIRE
Externí odkaz: